Bit-by-bit autophagic removal of parkin-labelled mitochondria
نویسندگان
چکیده
منابع مشابه
pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit.
A ccumulation of damaged mitochondria is prevented by their disposal through mitophagy, a mitochondrial quality control pathway. The protein kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin cooperate to initiate mitophagy by selective ubiquitination of protein substrates located on the mitochondrial outer membrane. Function-compromising mutations in PINK1 and Parkin genes predispose to here...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2013
ISSN: 2041-1723
DOI: 10.1038/ncomms3428